Yilmaz, Habibe2024-06-122024-06-1220220022-23481525-609Xhttps://doi.org/10.1080/00222348.2022.2119328https://hdl.handle.net/20.500.14551/18373Nowadays antibiotic resistance is one of the most serious problems. Therefore, there is a need for sustained and controlled drug release systems for antibiotics. The aim of this study was to develop a nano-antibiotic system using biocompatible and antimicrobial polymers that are abundant in nature. Frequently used amoxicillin was chosen as the antibiotic. Before nanoparticle synthesis kappa-carrageenan was oxidized and 1.2% carboxyl, and 23.08% aldehyde groups were obtained, as confirmed by Fourier-transform infrared spectroscopy. A combination of polyelectrolyte complexation and ionic gelation was occurred in the nanoparticle synthesis. For the optimal temperature, CaCl2 concentration and polymer ratio of 37 degrees C, 1.5% and 6:1, respectively, the results of hydrodynamic size measurements indicated the size was 414.4 nm. Drug loading encapsulation was successful with an efficiency of 73.28%. Drug release was monitored for 95 h, and drug release was 93% and 85%, respectively, at pH 6.0 and pH 7.4. It is shown by the mathematical models that the drug release profile can be explained by the Higuchi and first-order models since R-2 values were higher than for the other models. As a result, it was observed that the obtained nano-antibiotic delivery system performed a long-term drug release of approximately 4 days in a pH-sensitive manner and would be a promising drug delivery system.en10.1080/00222348.2022.2119328info:eu-repo/semantics/closedAccessAmoxicillinChitosanDrug DeliveryOxidized Kappa-CarrageenanPolymeric NanoparticleChitosan/Carrageenan NanoparticlesThermoreversible GelationArticle617-8926941Q4WOS:0008516132000012-s2.0-85138301014Q3