Kocyigit, Umit MuhammetEruygur, NuraniyeAtas, MehmetTekin, MehmetTaslimi, ParhamGokalp, FaikGulcin, Ilhami2024-06-122024-06-1220222619-9149https://doi.org/10.18016/ksutarimdoga.vi.895616https://search.trdizin.gov.tr/yayin/detay/1171146https://hdl.handle.net/20.500.14551/18800The research was conducted to separately evaluate and detect the possible in vitro antioxidant, antimicrobial activity of ethanol extracts prepared from aerial parts and roots of Astragalus dumanii and anti-cholinesterase and alpha-glucosidase inhibitory activity from only aerial parts of its The antioxidant capacity was tested by scavenging of DPPH and ABTS free radicals. Compared with the standard antioxidant compound gallic acid; Root and aerial part extract showed lower DPPH radical scavenging activity, however aerial part extract demonstrated higher ABTS radical scavenging activity. The phenolic contents were detected as 5.31 +/- 0.03 and 13.23 +/- 0.05 mg gallic acid equivalent g-1 extract, flavonoid contents were found as 8.26 +/- 0.004 and 7.93 +/- 0.005 mg Qercetin equivalent g-1 extract. In addition, the effects of the extracts obtained from aerial parts of the plant on acetylcholinesterase, butyrylcholinesterase and a-glycosidase enzymes were investigated in vitro and IC50 values were obtained as 1.47, 0.83 and 0.48 mu g mL-1, respectively. When these values were compared with standard substances, it was seen that Astragalus dumanii could be a good enzyme inhibitory agent. Antimicrobial activity of the plant extracts were determined using the microdilution method and the extracts was not observed to have any antimicrobial activities..en10.18016/ksutarimdoga.vi.895616info:eu-repo/semantics/openAccessAstragalus DumaniiAntioxidantAntidiabeticAcetylcholinesteraseButyrylcholinesteraseCarbonic-AnhydraseAcetylcholinesteraseButyrylcholinesteraseInhibitorsExtractsArticle25110N/AWOS:0008994197000011171146