Karadag, CHDokmeci, DDost, TUlugol, ADokmeci, I2024-06-122024-06-1220000100-879Xhttps://doi.org/10.1590/S0100-879X2000000300011https://hdl.handle.net/20.500.14551/22541We have shown that morphine has an anticonvulsive effect against maximal electroconvulsive shock (MES) in mice, and this effect is antagonized by histamine Hi-receptor antagonists. Brain histamine is localized both in neurons and in mast cells, and morphine is known to enhance the turnover of neuronal histamine and to release histamine from mast cells. In the present experiments, compound 48/80 was injected chronically (0.5 mg/kg on day 1, 1 mg/kg on day 2, 2 mg/kg on day 3, 3 mg/kg on day 4, and 4 mg/kg on day 5, twice daily, ip) to deplete mast cell contents. Morphine (0.001-10 mg/kg, ip; N = 20) produced a dose-dependent anticonvulsive effect against MES seizure in mice with non-depleted mast cells, whereas it did not exert any anticonvulsive effect in mice with depleted mast cells. These results indicate that morphine produces its anticonvulsive effect against maximal electroconvulsive shock in mice by liberating histamine from mast cells.en10.1590/S0100-879X2000000300011info:eu-repo/semantics/openAccessMorphineAnticonvulsive EffectHistamineMast CellsCompound 48/80ElectroshockElectrically-Induced ConvulsionsCentral Nervous-SystemMast-CellsReceptor AntagonistBrain HistamineMouse-BrainRatTransmitterReleaseArticle333327330Q3WOS:0000861310000112-s2.0-003411819410719385Q1