Tuglu, CengizSahin, Oezlem Oeztuerk2024-06-122024-06-1220101302-6631https://hdl.handle.net/20.500.14551/18548Tianeptine is a dibenzothiazepine type an atypical, tricyclic antidepressant. Biochemically it has been shown that after single or repeated administration, tianeptine increases the presinaptic reuptake of serotonine at the brain and trombocytes. Tianeptine reduces the hypothalamic-pituitary-adrenal response to stress and antogonizes the behavoiral problems induced by stress. Its pharmacotherapotic effects are neither stimulant nor sedative. Addiction to antidepressant therapy is controversial and rarely defined at the literature. Here we represent the tolerance, withdrawal symptoms and treatment issues of the case whom misused tianeptine at extremly high doses. (Anatolian Journal of Psychiatry 2010; 11:190-193)trinfo:eu-repo/semantics/closedAccessAntidepressantTianeptineDrug AbuseAddictionArticle112190193Q4WOS:0002769429000152-s2.0-77952204242Q4