Kilic-Okman, TKucuk, MAltaner, S2024-06-122024-06-1220030015-0282https://doi.org/10.1016/j.fertnstert.2003.05.002https://hdl.handle.net/20.500.14551/22111Objective: To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E-2, FSH, LH, and T. Design: Controlled prospective study. Setting: University research laboratory. Animal(s): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age. Intervention(s): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 mug/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized. Main Outcome Measure(s): Number of mature follicles, endometrial thickness, and serum levels of hormones. Result(s): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ. Conclusion(s): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate. (C) 2003 by American Society for Reproductive Medicine.en10.1016/j.fertnstert.2003.05.002info:eu-repo/semantics/openAccessLetrozoleRatClomipheneEndometriumFollicleOvaryClomiphene CitrateStimulating-HormoneAromatase InhibitorWomenEstrogenArticle80613301332Q1WOS:0001872842000032-s2.0-034636690914667861Q1