Esgin H.Erda N.2024-06-122024-06-1220020733-8902https://hdl.handle.net/20.500.14551/17113Purpose. To determine if there are any corneal endothelial cell size and shape changes (and the time course of these changes) in subjects wearing rigid high gas-permeable (RGP) contact lenses for daily wear. Methods. Ninety-seven eyes of 57 new wearers were fitted with a fluoroperm contact lens material (Persecon92E, oxygen transmissibility (Dk)= 92×10-11). Prior to lens wear and after 1 week, 1 month, 3 months, 6 months, and 1 year, noncontact endothelial photographs were taken. Maximum cell size/Minimum cell size (Max/Min) was measured as an index of polymegethism and the relative frequency of 5-, 6-, and 7-sided cells was evaluated. Results. An increase in the ratio of Max/Min was present 1 week after lens fitting and increased further over the subsequent year. This study showed significant increase in endothelial polymegethism and in the relative frequency of 7-sided cells, but a significant decrease in the relative frequency of 6-sided cells. Conclusions. Daily-wear high Dk gas-permeable contact lenses can cause endothelial polymegethism and pleomorphism similar to those caused by soft and hard contact lenses.eninfo:eu-repo/semantics/closedAccessCorneal Endothelium; Pleomorphism; Polymegethism; Rigid Gas-Permeable Contact Lenses; Specular MicroscopyAdult; Article; Cell Size; Cell Structure; Contact Lens; Controlled Study; Cornea Disease; Cornea Endothelium; Female; Gas Permeability; Hard Contact Lens; Histopathology; Human; Major Clinical Study; Male; Pathophysiology; Soft Contact Lens; Specular Microscopy; Adolescent; Adult; Cell Count; Cell Size; Child; Contact Lenses; Corneal Diseases; Endothelium, Corneal; Female; Humans; Male; Middle AgedArticle28140432-s2.0-003616977711838988N/A