Ozlen, BurcuHatipoglu, Osman NuriOzdemir, LeventSut, NecdetAltiay, GundenizTabakoglu, Erhan2024-06-122024-06-1220092148-36202148-5402https://hdl.handle.net/20.500.14551/23867Aim: Small cell lung cancer (SCLC) is an aggressive tumour with a poor clinical course, but responsive to both chemotherapy and radiotherapy. Some clinical and laboratory parameters can predict survival in SCLC. The aim of this study was to analyze the survival and identify the prognostic factors that influence survival in SCLC. Material andMethod: Forty six consecutive SCLC patients who were planned for chemotherapy, enrolled in this study prospectively. We recorded basic characteristic properties and factors affecting prognosis for each patient. We determined their survival time and survival curves were calculated by the method of Kaplan and Meier analysis. Results: Median survival time was 338 days (95% confidence interval: 243-432). Survival ratio for one month was 89%, for 6 months 62% and for one year 45%. Significiant parameters (p< 0.05) evaluated by univariate analysis followed by multivariate analysis. In multivariate analysis liver metastas (Relative Risk (RR): 4.99, 95% confidence interval: 1,21 -20,53), weight loss (RR: 11.3, 95% confidence interval 1,11-115,5) and low level of total protein after first chemotherapy (RR: 0.198, 95% confidence interval 0,06-0,63) were found as independent factors affecting survival. Conclusion: SCLC is a disease with high mortality. Prognostic factors that we found, can be supported by further investigations.trinfo:eu-repo/semantics/closedAccessSmall Cell Lung CancerPrognostic FactorsKingdom Coordinating CommitteeLaboratory ParametersPleural EffusionCarcinomaStageSubcommitteeMetastasesPredictorsTherapyDiseaseArticle111712N/AWOS:000421849300002