Cermik, TFAltiay, GFirat, MFHatipoglu, ONBerkarda, S2024-06-122024-06-1220050969-8051https://doi.org/10.1016/j.nucmedbio.2004.12.003https://hdl.handle.net/20.500.14551/24177The aim of this study is to investigate the potential effect of increased arterial saturation of oxygen in the magnitude of technetium-99m-hexakis-isobutyl-isonitrile ((99)mTc-MIBI) uptake in tumor tissue and to compare the results with those of conventional Tc-99m-MIBI tumor imaging in the same patient with lung cancer. A total of 26 lung cancer patients underwent initial SPECT (I-SPECT) and after oxygen inhalation SPECT (O-2-SPECT). The early (ER) and delayed ratios (DR) Of O-2-SPECT mean +/- S.D. were significantly higher than those of I-SPECT mean +/- S.D. (2.07 +/- 0.57 vs. 1.90 +/- 0.48 and 2.02 +/- 0.45 vs. 1.83 +/- 0.39, respectively). There are increased rates for the relative tumor uptake of Tc-99m-MIBI by 9% for ER and 10% for DR on the O-2-SPECT compared to I-SPECT. We found that 99mTc-MIBI uptake increased significantly in the tumor tissue with O-2-SPECT compared to I-SPECT. In conclusion, 99mTc-MIBI scintigraphy is one of the main methods for differentiating viable and nonviable tissue fractions in tumors. We consider that 99mTc-MIBI uptake increase after oxygen inhalation is an indicator of positive acute cellular response of the tumor tissue to the rising tissue oxygen level. (c) 2005 Elsevier Inc. All rights reserved.en10.1016/j.nucmedbio.2004.12.003info:eu-repo/semantics/closedAccessTc-99m SestamibiOxygenHypoxiaLung CancerLung-CancerP-GlycoproteinBreast-CancerChemotherapeutic ResponseFluorodeoxyglucose UptakeIntratumoral DistributionMultidrug-ResistanceCell-LinesHypoxiaTechnetium-99m-SestamibiArticle322165170Q2WOS:0002276891000082-s2.0-1384430587415721762Q2