Ayvaz, SuleymanTuncel, Sedat AlpaslanCan, GurayCagli, BekirKaraca, TuranDemirtas, SelimElmaoglu, Muhammed2024-06-122024-06-1220151300-01441303-6165https://doi.org/10.3906/sag-1403-113https://search.trdizin.gov.tr/yayin/detay/172729https://hdl.handle.net/20.500.14551/19076Background/aim: To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL). Materials and methods: Twenty-four rats were divided randomly into four groups: control, BDL - 3 days, BDL - 2 weeks, and BDL - 4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL - 3 days group at the end of day 3, on the rats from the BDL - 2 weeks group at the end of day 14, and on the rats from the BDL - 4 weeks at the end of day 28. Results: When fibrosis scores generated in all groups were evaluated together, a strong negative correlation was detected between fibrosis scores and apparent diffusion coefficient (ADC) values measured using b 100 and b 500. ADC values obtained using b 100 were found to be significantly higher compared to the fibrosis observed in both the BDL - 2 weeks and BDL - 4 weeks groups (P < 0.003 and P < 0.001, respectively). Conclusion: We think that DWI may be an alternative to liver biopsy for the diagnosis and staging of hepatic fibrosis with underlying extrahepatic cholestasis.en10.3906/sag-1403-113info:eu-repo/semantics/openAccessBile Duct LigationHepatic FibrosisDiffusion-Weighted Magnetic ResonanceExperimental Extrahepatic CholestasisRatLiver FibrosisCirrhosisQuantificationParametersSequencesDiagnosisLesionsBiopsyMriArticle453686693Q4WOS:0003563578000332-s2.0-8492973148526281340Q3172729