Narin E.B.Öztekin I.Öztekin S.D.Top?cu G.Ö?ütmen B.Canik S.2024-06-122024-06-1220141305-5550https://doi.org/10.5222/GKDAD.2014.033https://hdl.handle.net/20.500.14551/16863Objective: To compare the effects of dopamine and mannitol which are used to reduce the negative effects of long-term cardio-pulmonary bypass (CPB) on kidney function in according to manner of administration and by the time. Material and Methods: Group 1 (n = 25 patients): Mannitol (M) 1 g kg -1 was added to a priming solution of CPB. Group 2 (n = 25 patients): Dopamine infusion (D) (2 mg kg-1 min-1 IV) was used from induction of anesthesia until end of the operation. Group 3 (n = 25 patients): D (2 mg kg-1 min-1 IV) was used from induction of anesthesia until end of the operation and M 1 g kg-1 in the priming solution of CPB. Group 4 (n = 25 patients) (Control Group): Furosemide was performed in case of a decrease of urine. The values of serum urea, creatinine, albumin, urine microalbumin, urine creatinine, serum cystatin-C were compared to preop and postop periods. Results: Postop Cystatin C levels in Group I, II, III were observed a significant rise. The levels of Microalbumin / creatinine ratio in urine in all the groups at postop were seen advanced statistical significant (p <0.01). Conclusion: To determine kidney damage we have observed that microalbumin / creatinine ratio in urine compared to the Cystatin C level is to be a more sensitive parameter. We think that the use of D (2 ?g kg -1 min-1) combined with M (1 g kg-1) added during CPB is more effective in terms of preventing adverse effects of CPB on renal function.tr10.5222/GKDAD.2014.033info:eu-repo/semantics/openAccessCoronary Surgery; Cystatin-C; Dopamine; Mannitol; MicroalbuminAlbumin; Creatinine; Cystatin C; Dopamine; Furosemide; Mannitol; Urea; Albumin Blood Level; Anesthesia Induction; Article; Comparative Study; Controlled Study; Coronary Artery Bypass Surgery; Creatinine Blood Level; Human; Kidney Function; Major Clinical Study; Urea Blood Level; Urine LevelArticle20133402-s2.0-84899065138N/A