Alagöl A.Kaya G.Çolak A.Karaçayir Y.Pamukçu Z.Turan F.N.2024-06-122024-06-1220061304-0871https://hdl.handle.net/20.500.14551/17524Aim: The effectiveness of dexmedetomidine infusion on preventing hemodynamic response to intubation, skull pins and surgical incision in craniotomies was evaluated. Materials and Methods: Fourty ASA I-II patients undergoing craniotomy because of supratentorial tumors were randomised into: study group (n=20) received 1 ?g kg h-1 dexmedetomidine, and control group (n=20) received 0.9% NaCl infusion, 5 min. prior to induction. After intubation was performed at 10th minute, infusion rates were reduced to 50% in both groups. Control group received 1 ?g kg-1 fentanyl; dexmedetomidine group received 0.9% NaCl intravenously before skull pins. Same drugs were administered to the both groups for premedication, induction and maintenance. Results: Heart rate, systolic and diastolic arterial pressures reduced at 5th minute of infusion compared to initial values in dexmedetomidine group (p<0.001). Systolic and diastolic arterial pressures reduced after induction in both groups (p<0.001). In control group, the three haemodynamic parameters were higher after intubation compared to before intubation (p<0.001); were higher at 1 (p<0.001) and 5 minutes (p<0.05) after skull pins compared to before intubation; heart rate, systolic and diastolic (p<0.05) arterial pressures were higher after surgical incision compared to before intubation (p<0.001). In dexmedetomidine group, intubation and surgical incision did not cause significant haemodynamic response; systolic (p<0.001) and diastolic (p<0.05) arterial pressures were lower at 5 th minute than 1st minute of skull pins. Six patients in control and no patients in dexmedetomidine group needed fentanyl after surgical incision (p<0.001). Conclusion: Dexmedetomidine infusion started before induction is effective for preventing haemodynamic responses to intubation, skull pins and surgical incision in craniotomies.trinfo:eu-repo/semantics/closedAccessCraniotomy; Dexmedetomidine; Haemodynamic Response; Incision; Intubation; Skull PinsDexmedetomidine; Fentanyl; Sodium Chloride; Article; Clinical Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Craniotomy; Diastolic Blood Pressure; Drug Effect; Heart Rate; Hemodynamics; Human; Randomized Controlled Trial; Systolic Blood PressureArticle3442362402-s2.0-33846518369N/A