Görgülü, AYalniz, EDemir, MÇobanoglu, S2024-06-122024-06-1219990177-7955https://hdl.handle.net/20.500.14551/21922The pathogenesis of low back pain and sciatica is poorly understood. In this prospective study, we determined local production of IgM and IgG in nucleus pulposus, serum and cerebrospinal fluid by rate nephelometry in patients with herniated lumbar disc (n = 20). Patients operated for anterior stabilizations because of fresh fracture in the lumbar or thoracolumbar spine and scoliosis constituted the control group (n = 10). In the patients with lumbar disc herniation, the ratio IgM(NP)/IgM(S) x 10(3), IgG(CSF)/IgG(S) x 10(3), and IgM(CSF)/IgM, x 103 was significantly increased when compared with control group values (p < 0.001). We found a close relationship of the ratio IgM(NP)/IgM(S) x 10(3) between low SLR (<40 degrees) (p = 0.02) and the duration of sciatric pain less than 2 months (p = 0.002). The results indicate a connection between the clinical findings and IgM production in nucleus pulposus. This fact may contribute in some way to the inflammatory origin of sciatica.eninfo:eu-repo/semantics/closedAccessImmunuglobulinsNucleus PulposusSciaticaNucleus PulposusPainArticle2624148N/AWOS:0000842035000022-s2.0-0033452493N/A