Muranli, Fulya Dilek Gokalp2024-06-122024-06-1220091018-4619https://hdl.handle.net/20.500.14551/21119Genotoxic and cytotoxic effect of different concentrations of Lambda-cyhalothrin (LCT) (3.75, 7.5, 15 and 30 mu M/ml) were investigated in human peripheral blood lymphocyte culture by chromosome aberration (CA) and flow cytometry (FC) assays. Human peripheral whole blood cultures were treated with four concentrations of LCT which were prepared by using distilled water and Dimethyl Sulfoxide (DMSO) for 48 hours. Although LCT did not significantly induce CA frequency in human peripheral blood, the insecticide showed a genotoxic effect due to decrease of Mitotic Index (MI) and G2 phase ratios and high concentrations of LCT demonstrated an accumulation of aneuploid population in early S phase that might mean its damaging effect on DNA molecule.eninfo:eu-repo/semantics/closedAccessFlow CytometryChromosome AberrationsHuman Peripheral Blood CultureLambda-CyhalothrinRat Bone-MarrowEpithelial-CellsAcute ToxicityIn-VitroCypermethrinPesticidesPermethrinInductionDursbanDamageArticle189A17581763Q4WOS:000270702400012