Canbaz, SDuran, EEge, TSunar, HCikirikcioglu, MAcipayam, M2024-06-122024-06-1220030171-64251439-1902https://doi.org/10.1055/s-2003-38983https://hdl.handle.net/20.500.14551/24592Background: Vitamin E has a strong antioxidant capacity, and has been used in several ischemia-reperfusion studies. The aim of this study was to investigate the effects of water-soluble vitamin E (alpha-tocopherol) on myocardial protection during coronary artery surgery. Methods: Water soluble vitamin E (100mg) in tepid saline (n = 14) or tepid saline alone (n = 16) was administered into the coronary arteries at the end of aortic cross-clamping. Cardiac troponin-1 (cTn-1), MB-isoenzyme of creatine kinase (CK-MB), myoglobin, blood gas, and lactate levels in systemic and coronary sinus blood and hemodynamic variables were assessed during and after the operation. Results: Eight hours after reperfusion, cTn-1 levels increased to 3.06 +/- 1.8 ng/ml and 6.97 +/- 3.9 ng/ml in the vitamin E group and control group, respectively (p = 0.01). Coronary sinus lactate concentration was 2.68 +/- 0.5 mmol/l in the vitamin E group and 4.01 +/- 1.5 mmol/l in the control group 60 minutes after reperfusion (p = 0.027). Conclusions: Administration of vitamin E into the coronary arteries before removal of the aortic cross-clamp can reduce myocardial cell injury and protect the myocardium from ischemia-reperfusion injury.en10.1055/s-2003-38983info:eu-repo/semantics/closedAccessVitamin EAlpha TocopherolTroponin ILactateIschemia-Reperfusion InjuryCoronary Artery Bypass GraftingTroponin-I ReleaseAlpha-TocopherolDouble-BlindHeartCardioplegiaPreventionOperationsArticle5125761Q2WOS:0001830389000012-s2.0-003844523012730811Q2