Cagli, BekirTemizoz, OsmanGenchellac, HakanUmit, HasanTosun, AlptekinCakir, Bilge2024-06-122024-06-1220112146-31232146-3131https://hdl.handle.net/20.500.14551/24087Objective: To determine the value of superparamagnetic iron oxide (SPIO)-enhanced MR imaging in malignant liver lesions. Materials and Methods: Twenty patients with various hepatic masses or metastases were investigated with 1 tesla MR. T1-weighted FLASH and double- echo TSE T2-weighted sequences were applied before and after contrast injection. Defining statistics were prepared according to pre and postcontrast signal intensity measurements. Results: In this study there were 11 patients with metastases, 4 patients with hemangioma, 4 patients with HCC and one patient with a hemangioma and a metastasis at the same time. In cases wheret we found only hemangiomas, in all sequences, S/N ratios (p=0.043) and T2-weighted double-echo TSE with long TE SI change (p=0.043) were significant. While in the hemangiomas in T2-weighted double-echo TSE with long TE there is an decrease in the C/N ratios; in cases with metastasis and HCC, compared to other sequences significant increase in C/N ratio in T2-weighted double-echo TSE with short TE sequences was detected. Conclusion: SPIO-enhanced MR imaging can be used as a non-invasive radiologic technique for the detection focal liver lesions, to determine the number of lesions and also has a value in differentiating the benign lesions (especially hemangiomas) from primary tumors or metastatic malignant lesions.trinfo:eu-repo/semantics/closedAccessSuperparamagnetic Iron Oxide (SPIO)Contrast-Noise RatioMR ImagingT1-Weighted FLASH And T2-Weighted Double-Echo TSE SequencesFocal Hepatic-LesionsContrast AgentsSpiral CtMrFerumoxidesMetastasesSafetyArticle283286292N/AWOS:000295492900012