Durmus-Altun, GAltun, AAktas, RGSalihoglu, YSYigitbasi, NO2024-06-122024-06-1220050914-7187https://doi.org/10.1007/BF02984608https://hdl.handle.net/20.500.14551/18368The purpose of the study was; (i) to deter-mine whether I-123-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with Tc-99m-DTPA radioacrosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent I-123-MIBG and Tc-99m-DTPA radioaerosol scintigraphy at the end of the treatment period. I-123-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after 'intravenous injection of the radiopharmaccutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of I-123-MIBG were determined. Two days after I-123-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. I-123-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T-1/(2) values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5,p = 0.02). I-123-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, Tc-99m-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.en10.1007/BF02984608info:eu-repo/semantics/closedAccessAmiodaronePulmonary ToxicityI-123-MIBGTc-99m-DTPA RadioaerosolScintigraphyLung ScintigraphyAerosolPermeabilityClearanceDiseaseExtractionRetentionMarkerInjuryArticle193217224Q4WOS:0002296878000082-s2.0-2104443481115981675Q2