Tuncbilek, NerminKaplan, MustafaAltaner, SemsiAtakan, Irfan H.Sut, NecdetInci, OsmanDemir, Mustafa Kemal2024-06-122024-06-1220090361-803X1546-3141https://doi.org/10.2214/AJR.08.1332https://hdl.handle.net/20.500.14551/1845925th National Radiology Congress -- 2004 -- Antalya, TURKEYOBJECTIVE. The aim of this study was to investigate dynamic contrast-enhanced MRI (DCE-MRI) for the noninvasive measurement of bladder cancer angiogenesis by correlation with microvessel density, histologic grade, and tumor staging, and to predict the outcome of local recurrence. MATERIALS AND METHODS. Twenty-four patients with bladder cancer were examined using DCE-MRI. Hemodynamic parameters obtained by DCE-MRI included peak time enhancement in the first minute (E-max/1) after contrast administration, second minute (E-max/2), third minute (E-max/3), fourth minute (E (max/4)), and fifth minute (E-max/5), and the steepest slope. Microvessel density was identified by immunostaining of endothelial cells using FVIII-related antigen. The Mann-Whitney U test, multivariate discriminant analysis, Spearman's correlation coefficient, and analysis of variance were used for statistical analysis. RESULTS. Correlation was seen between DCE-MRI parameters (E-max/1 and steepest slope) and microvessel density (p<0.05). E-max/1 and steepest slope were found to have a statistically significant correlation with histologic grade (p<0.05 and p<0.01, respectively). A significant difference was seen between groups of patients with and without local recurrence with regard to two of the DCE-MRI parameters (p<0.05 for E-max/1 and E-max/2). CONCLUSION. The contrast enhancement patterns on DCE-MRI are influenced by tumor angiogenesis, as reflected by elevated microvessel density expression. Therefore, they are valuable indicators for assessing tumor angiogenic activity and tumor neovascularization in bladder cancers.en10.2214/AJR.08.1332info:eu-repo/semantics/closedAccessAngiogenesisBladder CancerDynamic EnhancementMRITransitional-Cell CarcinomaInvasive Breast-CancerPrognostic-SignificanceMicrovessel DensityChemotherapyMetastasisRecurrenceExpressionFeaturesImagesConference Object1924949955Q1WOS:0002643589000182-s2.0-6384928102519304699Q1