Canakci, Fatma GulfesanEtoz, Osman2024-06-122024-06-1220222149-9063https://doi.org/10.4274/meandros.galenos.2021.37980https://search.trdizin.gov.tr/yayin/detay/1134211https://hdl.handle.net/20.500.14551/21694Objective: Hypericum perforatum L. (HP) (Hypericaceae) is used as a wound healing agent especially burns. Thus, the aim of this study was to evaluate the effect of an extract of HP on wound healing after tooth extraction with clinical, radiological and histopathological evaluations.Materials and Methods: A unilateral upper central incisor was extracted from the rats. The rats were divided into four control and four test groups and were sacrificed 7, 14, 28, and 56 days after tooth extraction. HP was used in the test groups. Wound healing was evaluated clinically, radiologically and histopathologically.Results: In clinical examinations, HP had a positive effect on wound healing. to the results of histopathological evaluations, with the use of HP, decrease in inflammation, better epithelial proliferation, connective tissue formation and cartilaginous tissue formation occurs. No effect was found on bone healing on radiological examination.Conclusion: After tooth extraction the use HP extract result in better wound healing by clinical and histopathological evaluations. Further studies are required to evaluate the effects of oral surgery.en10.4274/meandros.galenos.2021.37980info:eu-repo/semantics/openAccessHypericum Perforatum St John’ SWound HealingHypericaceaeWort Tooth ExtractionSt-Johns-WortAntibacterial ActivityOintmentWoundsOilsL.Article233269274N/AWOS:0008639814000031134211