Ertugrul, Abdullah SeckinTekin, YasinTalmac, Ahmet Cemil2024-06-122024-06-1220171476-41721476-4180https://doi.org/10.1080/14764172.2017.1334923https://hdl.handle.net/20.500.14551/20509Background: The aim of this study is to determine the suitability of the Er,Cr:YSGG and 940 +/- 15-nm diode laser for the treatment of generalized aggressive periodontitis and chronic periodontitis by measuring the levels of human -defensin-1 and IL-1. Patients and Methods: A total of 26 patients were included in this study. The study was designed as a split-mouth experiment. We performed scaling and root planing in the right maxillary quadrant, scaling and root planning + Er,Cr:YSGG laser in the left maxillary quadrant, scaling and root planning + 940 +/- 15-nm diode laser in the left mandibular quadrant, and only scaling and root planing in the right mandibular quadrant. The presence of human -defensin-1 and IL-1 was analyzed with an ELISA. Results: When the baseline and post-treatment human -defensin-1 levels and IL-1 levels of the study groups were evaluated, a decrease in human -defensin-1 and IL-1 were observed in the quadrant where the Er,Cr:YSGG laser was applied in both the generalized aggressive periodontitis group and the chronic periodontitis group. Conclusions: The use of the Er,Cr:YSGG laser at non-surgical periodontal treatment decreased both IL-1 and human -defensin-1 levels. It is likely that Er,Cr:YSGG laser is more suitable for the treatment of generalized aggressive periodontitis and chronic periodontitis.en10.1080/14764172.2017.1334923info:eu-repo/semantics/closedAccessDiode LaserErcr:YSGG LaserHuman -Defensin-1IL-1Er-Yag LaserHuman Gingival FibroblastsRoot SurfacesMicrobiological FindingsAdjunctive TherapyCalculus RemovalClinical-TrialSplit-MouthIn-Vitro980 NmArticle197409417Q3WOS:0004139689000072-s2.0-8502112167528557642Q2