Saricam, EsmaBulak, NeslihanOzyurt, EsraOzcan, Suat2024-06-122024-06-1220201693-96972355-4800https://doi.org/10.14693/jdi.v27i3.1127https://hdl.handle.net/20.500.14551/1853120th Scientific Congress of Asian-Pacific-Endodontic-Confederation (APEC) -- APR 24-27, 2019 -- Istanbul, TURKEYEliminating microorganisms in the root canal system is important for the success of regenerative endodontics. Objective: This study evaluated the effects of different antibiotic pastes used for regenerative endodontic procedures on dentin microhardness and the push-out bond strength of mineral trioxide aggregate (MTA) to root canal dentin. Methods: Sixty-four maxillary central incisors were instrumented and randomly divided into the following four groups (n = 16) for medicament treatment: triple antibiotic paste, amoxicillin+clavulanic acid, cefaclor, and control (no dressing). After 21 days, two root segments were obtained by sectioning the roots horizontally for push-out and microhardness evaluations. MTA was placed into the root canal of the sectioned segment for the push-out test. In the microhardness evaluation, three indentations were made at 500 and 1,000 mu m from the canal lumen. The arithmetic mean was then calculated for each distance. ANOVA with post hoc Scheffe test and t test were used for the statistical analyses. The significance level was set at p < 0.05. Results: No significant difference was found between the groups in terms of push-out bond strength (p > 0.05). Cefaclor and amoxicillin+clavulanic acid reduced the microhardness values of the dentin at 500 mu m (p < 0.05) while cefaclor had the lowest value at 1,000 mu m (p < 0.05). Conclusion: Cefaclor reduced the microhardness value more than the other medicaments did at a depth of 1,000 mu m. The pastes provided similar adhesion of MTA.en10.14693/jdi.v27i3.1127info:eu-repo/semantics/openAccessAntibioticsAugmentinCefaclorMineral Trioxide AggregateRegenerative EndodonticsOut Bond StrengthIntracanal MedicamentsChemical-StructureCombinationsMedicationRemovalCementsConference Object273114119N/AWOS:000605182600001