Kurt, AysegulAltintas, Subutay HanKiziltas, Mustafa VolkanTekkeli, Serife EvrimGuler, Eray MetinKocyigit, AbdurrahimUsumez, Aslihan2024-06-122024-06-1220180287-4547https://doi.org/10.4012/dmj.2016-380https://hdl.handle.net/20.500.14551/23764The aim of this study was to evaluate the amount of leached residual monomers from self-adhesive resin cements and evaluate their toxicity in-vitro. A total of 60 disk-shaped specimens (5 mm in diameter and 0.5 mm in thickness) were prepared from each cement (RelyX U200, SpeedCEM, G-Cem) (n=20). Specimens were immersed in artificial saliva and the amount of released monomers [urethane dimethacrylate (UDMA) and triethyleneglycol dimethacrylate (TEGDMA)] was identified. Then, the cytotoxicity and genotoxicity effect on cells were evaluated using the defined amounts of released monomers from cements. The highest monomer release was detected in G-Cem (p<0.05). The highest cytotoxicity value was identified from SpeedCEM (p<0.01) and the highest genotoxicity values were calculated from RelyX U200 (p<0.05). Released UDMA and TEGDMA from self-adhesive resin cements induced cytotoxicity and genotoxicity effect on cells.en10.4012/dmj.2016-380info:eu-repo/semantics/openAccessSelf-Adhesive Resin CementMonomer ReleaseCytotoxicityGenotoxicityElectrophoresis Comet AssayHuman Gingival FibroblastsSealants In-VitroDental CompositeDna-DamagePulp CellsCytotoxicityComponentsLymphocytesGlutathioneArticle3714048Q3WOS:0004306469000062-s2.0-8504131084129225277Q1