Yildiz, MustafaSoy, MehmetKueruem, TurhanYildiz, Banu Sahin2024-06-122024-06-1220072149-22632149-2271https://hdl.handle.net/20.500.14551/23444Objective: The purpose of this study was to test the hypothesis; that chronic inflammation may impair vascular function and lead to an increase of arterial pulse wave velocity (PWV) in patients with Wegener's granulomatosis (WG). Methods: We recruited 5 patients with WG and 5 healthy age and sex matched controls in this cross-sectional case-controlled study. Aortic PWV was determined by using an automatic device (Complior Colson, France), which allowed on-line pulse wave recording and automatic calculation of PWV. Results: The carotid-femoral (aortic) PWV was increased in patients with WG as compared with control group (p=0.04). Although we found positive correlation between MAN and heart rate (r=0.75, p=0.01), we did not find any significant correlation between PWV and anthropometric and other hemodynamic parameters (p>0.05). In addition, we found positive correlation between PWV and erythrocyte sedimentation rate in patients with WG (r=0.90, p=0.03). Conclusion: Pulse wave velocity is increased and arterial distensibility decreased in patients with WG. Measurements of carotid-femoral (aortic) PWV may provide an easy and noninvasive technique to identify patients at increased risk of arterial disease.eninfo:eu-repo/semantics/closedAccessPulse Wave VelocityArterial DistensibilityWegener's GranulomatosisInflammationHeart-RateBlood-PressureAtherosclerosisPathogenesisAssociationStiffnessArticle73281285N/AWOS:00025424410000917785217