Bakar, E.Ulucam, E.Cerkezkayabekir, A.Sanal, F.Inan, M.2024-06-122024-06-1220190753-33221950-6007https://doi.org/10.1016/j.biopha.2018.10.045https://hdl.handle.net/20.500.14551/21896We aimed to evaluate the ultrastructural effect of reversing cellular damage, occurring in rats due to ischemia-reperfusion (I/R) in the intestine, with naringin implementation through biochemical parameters. Rats were divided the sham/control, I/R and the naringin groups (n=7). For I/R group, 120 min of ischemia and 120 min of reperfusion was applied to the superior mesenteric artery. In the naringin group, after 120 min, 50 mg/kg naringin was implemented, and then 120 min of reperfusion was applied. Morphological evaluation was performed via Chiu score and electron microscopy. The antioxidant parameters were examined. Chiu score in I/R (p < 0.01) and naringin (p < 0.05) groups were higher than the sham/control group. In ultrastructural level some irregularity were observed in I/R group. Although it decreased in the naringin group, the damage was observed to continue. Malondialdehyde (MDA) amount and Superoxide dismutase activity (SOD) in I/R group were higher in comparison to the sham/control group (p < 0.01), while glutathione peroxidase activity (Gpx) was found to be lower (p < 0.01). SOD (p < 0.05) and MDA (p < 0.01) were decreased by naringin group. Gpx was decreased in I/R group compared to sham/control group (p < 0.01) and elevated due to naringin administration (p < 0.05). Catalase activity was observed to decrease in the naringin group compared to control and I/R groups (p < 0.01). It was determined that naringin provided limited healing at the ultrastructural level but also effected recovery within antioxidant parameters.en10.1016/j.biopha.2018.10.045info:eu-repo/semantics/openAccessIschemia-ReperfusionIntestineNaringinMalondialdehydeAntioxidant EnzymesIschemia/Reperfusion InjuryOxidative StressRat ModelVitamin-EKidneyOzoneProanthocyanidinFormaldehydeDysfunctionInhibitionArticle109345350Q1WOS:0004525391000372-s2.0-8505587251430399568Q1