New synthesis of novel 1,2-dihydrofuro[3,4-d]pyrimidines

Yilmaz, Aysen SuekinciKacan, Mesut2024-06-122024-06-1220170040-4020https://doi.org/10.1016/j.tet.2017.05.072https://hdl.handle.net/20.500.14551/23457We describe the synthesis of a novel class of compounds, 1,2-dihydrofuro[3,4-d]pyrimidines (15, 16, 18, 20) starting from dimethyl furan-3,4-dicarboxylate 6. Synthesis of these compounds consist of two basic parts: Formation of 4-(2-azido-2-oxoethyl)furan-3-carbonyl azide 11 by eight organic reactions and formation of final products by intramolecular cyclization after two selective Curtius rearrangements of acyl azides 11. (C) 2017 Elsevier Ltd. All rights reserved.en10.1016/j.tet.2017.05.072info:eu-repo/semantics/closedAccessPyrimidineFuro[3,4-D]PyrimidineAcyl AzideCurtius RearrangementIntramolecular CyclizationNucleosidesAnalogsNew synthesis of novel 1,2-dihydrofuro[3,4-d]pyrimidinesArticle733145094512Q2WOS:0004059776000012-s2.0-85020082660Q2