Gunduz, OzgurOltulu, CagatayGuven, RabiaBuldum, DilekUlugol, Ahmet2024-06-122024-06-1220111590-1874https://doi.org/10.1007/s10072-011-0761-7https://hdl.handle.net/20.500.14551/22696The aim of the present study was to develop a new experimental pain model by adapting the chronic constriction injury (CCI) model of the sciatic nerve to the exclusively sensory saphenous nerve in rats. Animals were divided into na < ve, sham, and two experimental groups, in which two or four 4-0 chromic gut ligatures were loosely ligated around the saphenous nerve. Then, behavioral signs of neuropathic pain were observed for 8 weeks. In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures. Pharmacological analysis was made in rats with four loose ligations; morphine and WIN 55,212-2, a cannabinoid agonist, reversed all of the modalities tested, whereas gabapentin only suppressed mechanical allodynia and amitriptyline only reduced mechanical hyperalgesia. Our data establish a rat model of saphenous CCI with significant allodynia and hyperalgesia, which is sensitive to a number of analgesic compounds.en10.1007/s10072-011-0761-7info:eu-repo/semantics/closedAccessNeuropathic PainAllodyniaHyperalgesiaAnimal ModelSaphenous NerveSpared Nerve InjuryPeripheral MononeuropathyMechanical AllodyniaCannabinoid AgonistDynamic ComponentsTactile AllodyniaDiabetic-RatsAmitriptylineHyperalgesiaLigationArticle32611351142Q3WOS:0002975468000192-s2.0-8485621617521909745Q1