Yüce M.A.Gücer F.Balkanli-Kaplan P.Sayin N.C.2024-06-122024-06-1220040390-6663https://hdl.handle.net/20.500.14551/17088We report the successful treatment of an unruptured ectopic pregnancy in a patient with extremely high ?-human chorionic gonadotropin concentrations. A 33-year-old woman, gravida 2, para 0, abortus 1, presented to our department due to menstrual delay. On transvaginal ultrasonography, she had an unruptured ectopic pregnancy (3.5 × 4.5 cm). Her initial ?-HCG concentration was 38,270 mIU/ml. The administration of methotrexate (50 mg/m2) was performed intramuscularly. Serum ?-HCG levels decreased > 15% between post-therapy days 4 (31,324 mIU/ml) and 7 (13,108 mIU/ml), and did not rise during the subsequent weekly controls. In selected cases with unruptured ectopic pregnancy and extremely high initial ?-HCG levels, medical management with a single-dose methotrexate regimen may be successful.eninfo:eu-repo/semantics/closedAccessHigh ?-Hcg; Methotrexate; Unruptured Ectopic PregnancyChorionic Gonadotropin Beta Subunit; Methotrexate; Adult; Article; Case Report; Color Ultrasound Flowmetry; Disease Course; Dizziness; Ectopic Pregnancy; Female; Hormone Blood Level; Hospital Admission; Human; Menstruation Disorder; Nausea; Transvaginal Echography; Treatment Outcome; Abortifacient Agents, Nonsteroidal; Adult; Chorionic Gonadotropin, Beta Subunit, Human; Female; Humans; Injections, Intramuscular; Methotrexate; Pregnancy; Pregnancy, EctopicArticle3132422432-s2.0-464425410815491075Q4