U?uzalp-Kaldir M.Yürüt-Çalo?lu V.Coşar-Alas R.Çermik T.F.Altaner Ş.Eskiocak S.Saynak M.2024-06-122024-06-1220071300-7467https://hdl.handle.net/20.500.14551/17400Objectives: To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters. Methods: Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem. Results: A clear protective effect of amifostine against radiation-induced late damage in liver and kidney was found with scintigraphic evaluation. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues. Conclusion: The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.trinfo:eu-repo/semantics/closedAccessAmifostine; Kidney/Radiation Effects; Liver/Radiation Effects; Radiotherapy/Yan Etki; Risk Factors; ToxicityAmifostine; Animal Experiment; Animal Model; Article; Controlled Study; Female; Kidney Injury; Kidney Scintiscanning; Liver Injury; Liver Scintiscanning; Nonhuman; Radiation Dose; Radiation Injury; Radiation Protection; Radiotherapy; Rat; Wistar RatArticle2231051172-s2.0-77953438873Q4