Dokmeci, Dikmen2024-06-122024-06-122012978-1-61779-776-7978-1-61779-775-02197-72242197-7232https://doi.org/10.1007/978-1-61779-776-7_17https://hdl.handle.net/20.500.14551/18592Testicular torsion is a medical urologic syndrome that constitutes a surgical emergency affecting newborns, children, and adolescent boys. The main pathophysiological event in testicular torsion is ischemia (torsion) followed by reperfusion (detorsion) of the testis, and multifactorial mechanisms seem to mediate this condition. Testicular damage after ischemia/reperfusion (I/R) is related to the duration of ischemia and to the severity of the torsion. I/R injury is associated with activation of neutrophils, inflammatory cytokines, and adhesion molecules with increased thrombogenicity, release of massive intracellular calcium, and overgeneration of reactive oxygen species and reactive nitrogen species. Although the results are not conclusive and the molecular mechanism by which antioxidants control male fertility have not yet been clearly identified, several antioxidant enzymes and antioxidant drugs have been studied to prevent such I/R injury in testis. Antioxidant therapy may represent a new option within a broader therapeutic strategy in testicular torsion with oxidative stress-mediated infertility.en10.1007/978-1-61779-776-7_17info:eu-repo/semantics/closedAccessAntioxidantIschemia/ReperfusionLipid PeroxidationMale InfertilityOxidative StressReactive Oxygen/Nitrogen SpeciesTesticular TorsionIschemia-Reperfusion InjurySpermatic Cord TorsionAntioxidant Enzyme-ActivitiesActivated Protein-KinasesEndothelial Growth-FactorCell-Adhesion MoleculesTerm Histologic DamageNitric-Oxide SynthasePhenethyl Ester CapeAlpha-Lipoic AcidBook Chapter355398N/AWOS:0003031327000172-s2.0-85026293293N/A