Ertik, OnurKolanc, HakanYanardag, Refiye2024-06-122024-06-1220240019-5103https://doi.org/10.56042/ijc.v63i3.5887https://hdl.handle.net/20.500.14551/22010Coumarins are compounds commonly found in nature and have many biological effects. So it is a molecule that continues to be popular. Benzocoumarin and benzochromone, which are coumarin derivatives, are a group of molecules obtained from plants and it is important to understand the biological activity of the derivatives of these molecules. In our study, the inhibitory effects of newly synthesized 9-hydroxy-1-methyl-3H-naphto[2,1-b]piran-3-on (benzocoumarin) (1) and 9-hydroxy-2-methyl-4H-naphto[2,1-b]piran-4-on (benzochromone) (2) on elastase, hyaluronidase, collagenase, alpha-amylase, and alpha-glucosidase were investigated. As a result of in vitro studies, the inhibition effect of compounds 1 (132.64 +/- 16.12 mu M) and 2 (400.25 +/- 64.77 mu M)), was observed relative to the dose, only the inhibition effect on collagenase was found to have a lower IC(50 )value than the positive control (479.03 +/- 38.40 mu M). In line with the data obtained as a result of in vitro studies, molecular docking studies were also carried out for compounds 1 and 2 with collagenase. As a result, due to the inhibitory effect of compounds 1 and 2 on the collagenase activity, a way has been opened for further studies to prove it.en10.56042/ijc.v63i3.5887info:eu-repo/semantics/openAccessKeywords : BenzocoumarinBenzochromoneEnzyme InhibitionMolecular DockingADMEAlpha-GlucosidaseCollagenaseExpressionAmylaseArticle633253262N/AWOS:0011881006000062-s2.0-85188896275N/A