Mao, JingfangKocak, ZaferZhou, SuminGarst, JenniferEvans, Elizabeth S.Zhang, JunanLarrier, Nicole A.2024-06-122024-06-1220070360-3016https://doi.org/10.1016/j.ijrobp.2006.11.003https://hdl.handle.net/20.500.14551/2350947th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology -- OCT 16-20, 2005 -- Denver, COPurpose: To assess the impact of induction chemotherapy, and associated tumor shrinkage, on the subsequent radiation-related changes in pulmonary function and tumor response. Methods and Materials: As part of a prospective institutional review board-approved study, 91 evaluable patients treated definitively with thoracic radiation therapy (RT) for unresectable lung cancer were analyzed. The rates of RT-associated pulmonary toxicity and tumor response were compared in the patients with and without pre-RT chemotherapy. In the patients receiving induction chemotherapy, the rates of RT-associated pulmonary toxicity and tumor response were compared in the patients with and without a response (modified Response Evaluation Criteria in Solid Tumor criteria) to the pre-RT chemotherapy. Comparisons of the rates of improvements in pulmonary function tests (PFTs) post-RT, dyspnea requiring steroids, and percent declines in PFTs post-RT were compared in patient subgroups using Fisher's exact test, analysis of variance, and linear or logistic regression. Results: The use of pre-RT chemotherapy appears to increase the rate of radiation-induced pneumonitis (p 0.009-0.07), but has no consistent impact on changes in PFTs. The degree of induction chemotherapy-associated tumor shrinkage is not associated with the rate of subsequent RT-associated pulmonary toxicity. The degree of tumor response to chemotherapy is not related to the degree of tumor response to RT. Conclusions: Additional study is needed to better clarify the impact of chemotherapy on radiation-associated disfunction. (c) 2007 Elsevier Inc.en10.1016/j.ijrobp.2006.11.003info:eu-repo/semantics/openAccessRadiation-Induced PneumonitisPulmonary Function TestsTumor ResponseInduction ChemotherapyLung CancerConformal Therapy ConsortiumVolume Histogram AnalysisPulmonary-Function TestsDose-Escalation TrialCancer-PatientsBreast-CancerThoracic IrradiationRisk-FactorsFollow-UpPneumonitisConference Object67513601369Q1WOS:0002455675000102-s2.0-3394752608217276621Q1