Davis, Rohan A.Demirkiran, OzlemSykes, Melissa L.Avery, Vicky M.Suraweera, LekhaFechner, Gregory A.Quinn, Ronald J.2024-06-122024-06-1220100960-894Xhttps://doi.org/10.1016/j.bmcl.2010.05.091https://hdl.handle.net/20.500.14551/17912Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone ( 1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 mu M. (C) 2010 Elsevier Ltd. All rights reserved.en10.1016/j.bmcl.2010.05.091info:eu-repo/semantics/closedAccess7 ',8 '-DihydroobolactoneCryptocarya ObovataAntitrypanosomalTrypanosoma Brucei BruceiMCF-7A549HelaHEK293Trypanosoma-BruceiFlavonoidsAlkaloidsDrugArticle201440574059Q2WOS:0002792588000132-s2.0-7795387182820558060Q2