Uzgur, SeldaUsta, UfukGoekmen, Selma Sueer2024-06-122024-06-1220110250-4685https://hdl.handle.net/20.500.14551/22177Objectives: To investigate the effect of L-lysine on serum total and lipid-bound sialic acid levels in isoproterenol-induced myocardial infarction and to evaluate the role of cell damage in the elevation of sialic acid post-infarction. Material and Methods: Male albino rats of Wistar strain were divided into three groups randomly: control, isoproterenol and isoproterenol+L-lysine. Myocardial infarction was produced with 150 mg/kg of isoproterenol administered intraperitoneally twice at an interval of 24 hour. L-Lysine was given orally (5 mg/kg/day) for 5 days. Existence of experimental infarction was confirmed by histopathological changes and the elevation of troponin I. The levels of serum total and lipid-bound sialic acid were determined by the methods of Warren and Katopodis, respectively. Results: Isoproterenol caused a significant elevation in serum troponin I, total and lipid-bound sialic acid levels and a prominent atrophy and fibrotic changes confirming myocardial infarction in heart tissue. L-Lysine significantly prevented troponin I, total and lipid-bound sialic acid increase in serum and atrophy and connective tissue development in heart tissue. Conclusion: Cell damage may play an important role in serum sialic acid elevation after myocardial infarction. Conflict of interest: The authors have no conflict of interest.trinfo:eu-repo/semantics/closedAccessL-LysineTotal And Lipid-Bound Sialic AcidTroponin IExperimental Myocardial InfarctionCell DamageAcute-Phase ProteinsL-ArginineCardiovascular-DiseaseUrea CycleArginaseDamageCellsInflammationReperfusionMetabolismArticle363248254Q4WOS:0003009744000102-s2.0-84858227291Q4