Guldiken, BaburhanGuldiken, SibelTurgut, BurhanTurgut, NildaDemir, MuzafferCelik, YahyaArikan, Ender2024-06-122024-06-1220080003-3197https://doi.org/10.1177/0003319707304134https://hdl.handle.net/20.500.14551/21986The role of circulating, oxidized low-density lipoprotein and interleukin-6 levels in acute ischemic stroke considering the primary-vessel disease was investigated. The study consisted of 28 patients with acute ischemic stroke and 23 control subjects. Patients were subdivided into large-vessel (n = 12) and small-vessel (n = 16) disease stroke groups according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The means of oxidized low-density lipoprotein and interleukin-6 levels of patients with acute ischemic stroke were higher than controls (P < .01, P < .05). Mean oxidized low-density lipoprotein level was higher in the large-vessel disease group than in the small-vessel disease group (P < .01). The mean of inteleukin-6 levels was higher in the small-vessel disease group (P < .01). The results of the present study showed that oxidative stress promotes large-vessel disease rather than small-vessel disease stroke, and inflammation may play important an role in the development of small-vessel disease stroke.en10.1177/0003319707304134info:eu-repo/semantics/closedAccessIschemic StrokeOxidized Low-Density LipoproteinInterleukin-6AtherosclerosisProinflammatory CytokinesAdhesion MoleculesLdlInflammationExpressionDiseaseMarkerAtherosclerosisActivationInfarctionArticle592224229Q4WOS:0002551372000142-s2.0-4204909890918388043Q2