Altiay, G.Ciftci, A.Demir, M.Kocak, Z.Sut, N.Tabakoglu, E.Hatipoglu, O. N.2024-06-122024-06-1220070936-65551433-2981https://doi.org/10.1016/j.clon.2007.04.002https://hdl.handle.net/20.500.14551/20345Aims: An elevated plasma D-dimer level indicates the activation of coagulation and fibrinolysis. In the present study, we investigated the association of pre-treatment haemostatic parameters (D-dimer, fibrinogen and prothrombin fragment 1 + 2) with clinicopathological parameters and outcome in patients with lung cancer. Materials and methods: Plasma levels Of D-dimer and other parameters were measured in 78 evaluable patients with lung cancer (60 non-small cell lung cancers, 18 small cell lung cancers). At diagnosis, 35 patients (44.9%) were locally advanced stage (IIIA/B) and 43 patients (55.1%) had metastatic disease (IV). Multivariate statistical analysis was carried out using Cox's proportional hazards model. The receiver operating characteristic curve was used to determine the cutoff values for D-dimer, fibrinogen and prothrombin fragment 1 + 2. Results: The median survival for all patients was 264 days (95% confidence interval 200-328 days). A significant association between the plasma levels Of D-dimer and the response to chemotherapy was observed (P = 0.03). With the univariate analysis, tumour stage, pre-treatment plasma levels Of D-dimer, fibrinogen, platelet count, lactate dehydrogenase concentration and Karnofsky performance status were predictive for survival. With the multivariate analysis (P <= 0.11), the plasma level Of D-dimer (P < 0.001), tumour stage (P = 0.01) and Karnofsky performance status (P = 0.02) were identified as independent predictive factors. The median survival times were 405 days (95% confidence interval 165-644 days) and 207 days (95% confidence interval 146-267 days, P < 0.001), respectively, for patients with a low D-dimer level (<= 0.65 mu g/ml) and a high D-dimer level (> 0.65 mu g/ml). Conclusions: Elevated plasma levels Of D-dimer in patients with lung cancer are associated with decreased survival and a poor response to treatment. Pre-treatment for the D-dimer level may be useful in the prediction of survival and the response to treatment.en10.1016/j.clon.2007.04.002info:eu-repo/semantics/closedAccessD-DimerLung CancerPrognosisMolecular-Weight HeparinPrognostic-SignificanceTumor StageCoagulationAnticoagulationAbnormalitiesCarcinomaSystemArticle197494498Q3WOS:0002492315000032-s2.0-3454754018817513096Q1