Kocak, ZaferShankar, LalithaSullivan, Daniel C.Marks, Lawrence B.2024-06-122024-06-122008978-3-540-49069-20942-5373https://hdl.handle.net/20.500.14551/24822The recognition and assessment of normal tissue injury is an important aspect of radiation oncology practice and a critical endpoint in clinical studies. One of the major challenges in the study of radiation (RT)-induced normal tissue injury is determining the appropriate endpoint. Patients' symptoms have obvious clinical relevance; however, the scoring of symptoms is relatively subjective. Conversely, radiologic endpoints are potentially quantifiable and are available for objective I study. Furthermore, radiologic evidence of subclinical normal tissue injury is far more common than are clinical symptoms, providing a larger number of patients with identifiable injury for study. We review herein radiologically-detected normal tissue injury as it relates to the lung, heart, brain, and salivary glands. The concepts described are likely to be similar for other organs. We conclude that: (1) radiologically-defined normal tissue injury in human patients may be related to long-term clinically meaningful injury, but further study is needed to better quantify this association; (2) radiologically-defined normal tissue injury in human patients is manifest soon after (or even during) RT and hence is a potential tool to rapidly study potential mitigators of this injury in humans; and (3) additional work is needed to develop standards to quantitatively score radiologic injury. Thus, advances in anatomic and functional imaging afford unique opportunities to facilitate the study of radiation-associated normal tissue injury.eninfo:eu-repo/semantics/openAccessBreast-Cancer PatientsDose-Volume HistogramEmission Computed-TomographyLocal Pulmonary InjuryCell Lung-CancerAdjuvant RadiotherapyFollow-UpMalignant-LymphomaGlucose-MetabolismMyocardial DamageBook Chapter3745N/AWOS:000267389600006