Beynek, NesrinTan, NurcihanBeynek, Hayrettin2024-06-122024-06-1220150792-12412191-0219https://doi.org/10.1515/mgmc-2015-0018https://hdl.handle.net/20.500.14551/18567A novel lead (II) complex of Schiff base containing three bipyridine units was synthesized by the template reaction between a new amine compound, 6-methyl-6'-(2-aminophenoxymethyl)-2,2'-bipyridine, and 2,2'-bipyridine-6,6'-dicarboxaldehyde in the presence of a Pb(II) perchlorate ion. The new amino compound and Schiff base complex, [PbL](ClO4)(2)center dot 2H(2)O, were characterized by using matrix-assisted laser desorption/ionization with time-of-flight mass spectroscopy, FAR FT-IR, UV/visible spectroscopy, H-1 NMR, elemental analyses (CHN), and molar conductivity measurements. Then the synthesized complex was screened in vitro for its antibacterial and antifungal activities against three Gram-negative and two Gram-positive bacteria and also against Candida albicans as a fungus by the microdilution broth method as a minimal inhibitory concentration. [PbL](ClO4)(2)center dot 2H(2)O exhibits moderate activity on Staphylococcus aureus and Listeria monocytogenes when compared with standard drug and also shows moderate antifungal activity on the fungus Candida albicans.en10.1515/mgmc-2015-0018info:eu-repo/semantics/openAccessAntimicrobial ActivityLead (II)Schiff BaseTemplate ReactionDonor MacrocyclesCrystal-StructureMetal-IonsCoordinationLigandsArticle385-6145150Q4WOS:0003665249000032-s2.0-84948746156Q3