Tac, DoganAytac, Ismet ArincKaratavuk, Ali OsmanKus, MelihZiyanak, FiratArtok, Levent2024-06-122024-06-1220172193-58072193-5815https://doi.org/10.1002/ajoc.201700225https://hdl.handle.net/20.500.14551/20848Acetate derivatives of 2-en-4-yne alcohols 1 and enyne oxiranes 4 regioselectively underwent 1,5-substitution (S(N)2 '') reactions with Grignard reagents in the presence of an iron compound to provide vinylallenes exclusively with the (E)-configuration. An alkali salt was needed to avoid the hydride-promoted reductive 1,5-substitution pathway for 1, whereas no such additive was needed for the effective conversion of 4 into the desired alkylated or arylated vinylallene structure.en10.1002/ajoc.201700225info:eu-repo/semantics/openAccessEnynesGrignard ReactionIronNucleophilic SubstitutionRegioselectivityElectrocyclic Ring-ClosureCross-Coupling ReactionsDiels-Alder ReactionsStereoselective-SynthesisCarbonyl-Compounds4+1 CycloadditionVinyl-AllenesVinylallenesKetonesEstersArticle61014151420Q2WOS:0004133551000172-s2.0-85025070187Q2