Demirci, HakanCinar, Yildirim2024-06-122024-06-1220100907-89161603-9629https://hdl.handle.net/20.500.14551/26176INTRODUCTION: Subjects (n = 46) with type 2 diabetes who responded inadequately to two and three oral medications (HbA(1C) > 8.0%) were consecutively recruited for treatment with premixed insulin 30/70 two times a day in order to investigate whether previous oral therapies may predict insulin requirements. MATERIAL AND METHODS: In this prospective study, men and women were eligible to participate if they were aged between 30 and 65 years, had had a diagnosis of type 2 diabetes mellitus for at least 12 months, were insulin-naive and had been treated unsuccessfully with either two or three oral antidiabetic drugs for at minimum of three months. Clinical and laboratory findings were analyzed at one year follow-up. RESULTS: The average required insulin doses were significantly higher in patients in whom previous triple oral medication had failed than in patients in whom two oral drugs had failed. CONCLUSIONS: Evaluation of the previous number of oral antidiabetic drugs and HbA(1C) values may help us predict the insulin requirement when oral drugs have failed.eninfo:eu-repo/semantics/closedAccess[No Keywords]Article5711Q2WOS:0002839949000052-s2.0-7864952985321055372N/A