Sogut, KubraGorgulu, YaseminPalabiyik, Orkide2024-06-122024-06-1220230803-94881502-4725https://doi.org/10.1080/08039488.2023.2251448https://hdl.handle.net/20.500.14551/19154Objective: A global approach to factors responsible for functional impairment in patients with BD is necessary.Method: Ninety-three euthymic patients with BD [49 patients with SD (subthreshold depression) and 44 patients without SD] and 48 healthy controls were invited for evaluation of demographic, clinical, and cognitive characteristics. To define SD, the lower limit was HDRS =4 points and the upper limit was HDRS <9 points. Stroop test, California verbal learning test, digit-span test, controlled word association test, and clock drawing test were performed. Serum BDNF levels were measured. Additionally in the BD group; blood drug (lithium, valproic acid), leukocyte, C-reactive protein (CRP), TSH, and vitamin B12 levels were measured.Results: We found no difference between serum BDNF levels of BD (n = 93) and controls. The cognitive performances of the BD group were worse than the control group (p < 0.001). Attention, working memory, and stroop performance of patients with SD were worse than patients without SD (p < 0.05). Verbal fluency, stroop test, and planning performance decreased as serum CRP level increased in patients with BD (p < 0.05).Conclusions: Although the patient group with SD was in euthymia, their cognitive performance was worse than the group without SD. Poor cognitive performance in BD was associated with serum CRP levels.en10.1080/08039488.2023.2251448info:eu-repo/semantics/closedAccessBipolar DisorderDepressionCognitionBDNFC-Reactive ProteinC-Reactive ProteinNeurotrophic FactorNeurocognitive FunctionResidual SymptomsEuthymic PatientsSerum-LevelsBrainBdnfPerformancePostmortemArticle778768777N/AWOS:0010619879000012-s2.0-8516979841437668000Q2