Ulugöl A.Karadag H.Dökmeci D.Dökmeci I.2024-06-122024-06-1219960513-5796https://doi.org/10.3349/ymj.1996.37.2.97https://hdl.handle.net/20.500.14551/16618Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.en10.3349/ymj.1996.37.2.97info:eu-repo/semantics/closedAccessBody Temperature; Compound 48/80; Histamine; Histamine Receptors; HypoxiaCompound 48-80; Dimetindene; Histamine H1 Receptor; Histamine H2 Receptor; Histamine Receptor; Ranitidine; Animal Experiment; Article; Body Temperature; Controlled Study; Convulsion; Drug Effect; Hypothermia; Hypoxia; Intraperitoneal Drug Administration; Male; Mouse; Nonhuman; Animals; Anoxia; Body Temperature; Male; Mice; Mice, Inbred Balb C; P-Methoxy-N-Methylphenethylamine; Receptors, Histamine H1; Receptors, Histamine H2; SeizuresArticle372971032-s2.0-00300386918711940Q2