Gültekin, AYüksel, MMert, SBerkarda, F2024-06-122024-06-1220050914-71871864-6433https://doi.org/10.1007/BF02984604https://hdl.handle.net/20.500.14551/2430415th Annual Congress of the European-Association-of-Nuclear-Medicine -- 2002 -- VIENNA, AUSTRIASurfactant secreted from type II pneumocytes plays an important role in alveolo-capillary permeability. In thyrotoxicosis, high levels of T3 receptors detected at these cells might affect the alveolocapillary permeability due to increased serum thyroid hormone levels. The results by CO-diffusion capacity measurement in thyrotoxicosis are conflicting. Changes in alveolo-capillary membrane permeability resulting from thyrotoxicosis are not well established yet. This prompted us to investigate the alveolo-capillary permeability in thyrotoxic patients in comparison with CO-diffusing capacity. For this aim twenty-two non-smoking thyrotoxic patients (before treatment) and fifteen healthy voluntary controls underwent Tc-99m-DTPA aerosol scintigraphy. CO-diffusing and pulmonary function tests were performed in all subjects. After ventilation of radiotracer through a nebulizer for 15 minutes, 30 dynamic images (1 frame/minute) were taken from both lungs. ROI's were drawn over both lung areas, and the time-activity curves were generated. Then clearance half time (CT1/2) for radioaerosol was obtained. CT1/2 of thyrotoxic patients did not differ from that of the controls: 77.9 +/- 25.9 min vs. 79.4 +/- 22.3 min; p > 0.05. Similar result was found for CO-diffusion parameters. Also there was no significant correlation between CT1/2 and CO-diffusion parameters. We concluded that in patients with thyrotoxicosis, the alveolo-capillary permeability is unaffected. Further experimental research is needed to establish the possible effects of thyroid hormones on alveolo-capillary membrane.en10.1007/BF02984604info:eu-repo/semantics/closedAccessThyrotoxicosisAlveolo-Capillary PermeabilityTc-99m DTPAAerosol ScintigraphyEpithelial PermeabilityLungClearanceHyperthyroidismConference Object193193196Q4WOS:0002296878000042-s2.0-2104443569915981671Q2