Tiyekli, UtkanCaliyurt, OkanTiyekli, Nimet Dilek2024-06-122024-06-1220131601-5215https://doi.org/10.1111/j.1601-5215.2012.00676.xhttps://hdl.handle.net/20.500.14551/20075Objective: It was aimed to evaluate the relationship between proinflammatory cytokine levels and conversion disorder both commonly known as stress regulated. Method: Baseline proinflammatory cytokine levels-[Tumour necrosis factor alpha (TNF-alpha), Interleukin-1 beta (IL-1 beta), Interleukin-6 (IL-6)]-were evaluated with enzyme-linked immunosorbent assay in 35 conversion disorder patients and 30 healthy controls. Possible changes in proinflammatory cytokine levels were evaluated again, after their acute phase in conversion disorder patients. Results: Statistically significant decreased serum TNF-alpha levels were obtained in acute phase of conversion disorder. Those levels increased after acute conversion phase. There were no statistically significant difference observed between groups in serum IL-1 beta and (IL-6) levels. Conclusions: Stress associated with conversion disorder may suppress immune function in acute conversion phase and may have diagnostic and therapeutic value.en10.1111/j.1601-5215.2012.00676.xinfo:eu-repo/semantics/closedAccessConversion DisorderCytokineInterleukin-1 BetaInterleukin-6Tumour Necrosis Factor AlphaTumor-Necrosis-FactorEpstein-Barr-VirusDissociative DisorderSomatoform DisordersStressImmunePsychoneuroimmunologyBenzodiazepinesGlucocorticoidsSensitizationArticle253137143Q4WOS:0003205508000032-s2.0-8487989993025287467Q2