Bulut, E.Ozturk, L.2024-06-122024-06-1220172498-602Xhttps://doi.org/10.1556/2060.104.2017.2.7https://hdl.handle.net/20.500.14551/22942We hypothesized that cochlear frequency discrimination occurs through medial olivocochlear efferent (MOCE)-induced alterations in outer hair cell (OHC) electromotility, which is independent from basilar membrane traveling waves. After obtaining informed consent, volunteers with normal hearing (n = 10; mean age: 20.6 +/- 1.2 years) and patients with unilateral deafness (n = 10; mean age: 30.2 +/- 17.9 years) or bilateral deafness (n = 8; mean age: 30.7 +/- 13.8 years) underwent a complete physical and audiological examination, and audiological tests including transient evoked otoacoustic emission and spontaneous otoacoustic emission (TEOAE and SOAE, respectively). SOAE recordings were performed during contralateral pure-tone stimuli at 1 and 3 kHz. SOAE recordings in the presence of contralateral pure-tone stimuli showed frequency-specific activation out of the initial frequency range of SOAE responses. Basilar membrane motion during pure-tone stimulation results from OHC activation by means of MOCE neurons rather than from a traveling wave. Eventually, frequency-specific responses obtained from SOAEs suggested that OHC electromotility may be responsible for frequency discrimination of the cochlea independently from basilar membrane motion.en10.1556/2060.104.2017.2.7info:eu-repo/semantics/openAccessOtoacoustic EmissionsSpontaneousHair CellsAuditoryOuterCochleaAudiometryPure-ToneMedial Olivocochlear EfferentsOuter Hair-CellsCochlear AmplificationMammalian CochleaMotor ProteinPrestinStimulationMechanicsMoleculesMotionCortiArticle1042171182Q4WOS:0004090669000072-s2.0-8502183701928648121Q3