Demirkiran, Ozlem2024-06-122024-06-1220121874-39001876-7486https://doi.org/10.1016/j.phytol.2012.06.018https://hdl.handle.net/20.500.14551/21697Purification of n-BuOH fraction from 80% ethanol extract of Hypericum thasium Griseb. resulted in the isolation of three new compounds 3',4,5'-trihydroxy-6-methoxy-2-O-alpha-L-arabinosylbenzophenone (1), 3',4,5',6-tetrahydroxy-2-O-alpha-L-arabinosylbenzophenone (2), and 3',4-dihydroxy-5'-methoxy-2-O-alpha-L-arabinosyl-6-O-beta-D-xylosylbenzophenone (3) along with a known flavonoid glycoside quercetin-3-O-alpha-L-arabinofuranoside (4). The structures of the new compounds were elucidated by 1D and 2D NMR analysis as well as HRESIMS. The isolated compounds (1-4), as well as quercetin, and kaempferol previously isolated from EtOAc fraction were screened against MAO-A inhibitory activity. When tested against the MAO-A quercetin and kaempferol displayed IC50 values of 19.6, and 17.5 mu M, respectively. The IC50 values for MAO-A inhibition by compounds (1-4) were 310.3, 111.2, 726.0, and 534.1 mu M, respectively. Standard inhibitor (clorgyline) exhibited MAO-A inhibition with an IC50 value of 0.5 mu M. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.en10.1016/j.phytol.2012.06.018info:eu-repo/semantics/closedAccessHypericum Thasium Griseb.Benzophenone GlycosidesMAO-AAntidepressantsSt-Johns-WortMonoamine-OxidaseXanthonesIdentificationDepressionAssignmentQuercetinExtractsPlaceboNmrArticle54700704Q3WOS:0003113373000032-s2.0-84869500753Q2