Korkmaz, SelmaFicicloglu, Sezin Kuru2024-06-122024-06-1220181642-395Xhttps://doi.org/10.5114/ada.2017.71286https://hdl.handle.net/20.500.14551/17995Introduction: Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit. Although various mechanisms have been indicated in the etiopathogenesis of acne vulgaris, the exact pathophysiology is still unknown. Aim: To investigate the level of calprotectin in acne vulgaris and its levels relationship with disease severity. Material and methods: A total of 66 AV patients, who were divided into 33 mild and 33 moderate-severe cases, and 30 healthy controls were enrolled in the study. Disease severity was assessed using the Global Acne Score. According to this scale, patients whose Global Acne Score was 1-18 had mild acne, those with a score of 19-30 had moderate acne, those with a score of 31-38 had severe acne, and those with a score greater than 39 had very severe acne. Serum calprotectin levels of all participants were measured by enzyme-linked immunosorbent assay method. Results: The serum calprotectin levels in the moderate-severe AV group were significantly higher than that of the mild AV group (p < 0.001). In addition, the scrum calprotectin level in the mild AV group was significantly higher than that of the healthy control group (p = 0.047). However, in the Spearman's correlation analysis, the scrum calprotectin level and GAS were not correlated in AV patients (p = 0.171, r = 0.179). Conclusions: Serum calprotectin levels are increased in mild and moderate AV patients.en10.5114/ada.2017.71286info:eu-repo/semantics/openAccessAcne VulgarisCalprotectinInflammationS100a9Article354397399Q3WOS:0004425396000122-s2.0-8505211172830206454Q3