Guldiken, SibelDemir, MuzafferArikan, EnderAzcan, SennurTugrul, Armagan2024-06-122024-06-1220081051-2144https://doi.org/10.1097/TEN.0b013e3181652c8dhttps://hdl.handle.net/20.500.14551/21730Hypothyroidism is associated with an increased risk for obesity and cardiovascular diseases. Resistin and leptin exert proinflammatory actions by activating a specific receptors which are expressed in human endothelial cells. The aim of the study was to investigate whether the relations between the leptin, resistin, and high-sensitivity C-reactive protein (hs-CRP), which is a marker of low-grade inflammation, in patients with subclinical (SH) and overt hypothyroidism (OH). The levels of leptin, resistin, and hs-CRP were measured in 25 patients with CH, 30 patients with SH, and in 25 healthy subjects, using enzyme-linked immunosorbent assay method. The leptin and resistin levels in patients with OH and SH were similar to those in the control group. The hs-CRP level in OH group was significantly higher than SH and control groups (P < 0.001, P < 0.001). In the OH group, hs-CRP levels were positively correlated with thyroid-stimulating hormone levels (P < 0.001, r = 0.728) and negatively correlated with fF4 levels (P = 0.01 r = -0.51). Combining the OH and SH groups, serum hs-CRP levels were significantly correlated with thyroid-stimulating hormone levels (P < 0.001, r = 0.765) and fr4 (P < 0.001, r = -0.716). No significant correlation was found between hs-CRP and leptin or resistin in patients with OH and SH. We suggest that the elevated hs-CRP levels in hypothyroidism may play a role in the increased risk for atherosclerosis in these patients.en10.1097/TEN.0b013e3181652c8dinfo:eu-repo/semantics/closedAccessHypothyroidismLeptinResistinC-Reactive ProteinEndothelial DysfunctionCardiovascular Risk-FactorsAdipose-TissueMechanismsDiseaseInflammationDysfunctionExpressionObesityArticle1813033Q4WOS:0002529391000102-s2.0-40049104187N/A