Soyucen, ErdoganYilmaz, SemaCeltik, CoskunVatansever, UlfetOner, NaciKarasalihoglu, Serap2024-06-122024-06-1220101300-4948https://doi.org/10.4318/tjg.2010.0093https://search.trdizin.gov.tr/yayin/detay/109476https://hdl.handle.net/20.500.14551/18895Background/aims: We aimed to estimate the seroprevalence of celiac disease, a gluten-sensitive enteropathy, and autoimmune thyroiditis in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey. Methods: The population studied consisted of 33 children with insulin-dependent diabetes mellitus and 41 healthy children with demographic features similar to the study subjects. Free triiodothyronine, free thyroxine, thyroid-stimulating hormone, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, IgA, anti-endomysium IgA, and anti-gliadin IgA were measured in all cases and controls. Results: The serum levels of free triiodothyronine and free thyroxine were within the normal range in all cases. However, in one patient who had anti-thyroid peroxidase and anti-thyroglobulin antibodies, the thyroid-stimulating hormone level was high despite a normal free triiodothyronine and free thyroxine value. Ultrasonographic findings confirmed thyroiditis in this patient. Anti-thyroid peroxidase antibodies, anti-thyroglobulin antibodies, anti-endomysium IgA and anti-gliadin IgA were detected in 15.4%, 6%, 9.1% and 3% of the diabetic cases, respectively. None of these antibodies was detected in the control group. In the diabetic group, the seroprevalences of the antithyroid peroxidase antibodies and the anti-endomysium IgA were statistically higher than in the control group (p<0.05). Conclusions: Children with insulin-dependent diabetes mellitus in our region should undergo periodic screenings for autoimmune thyroiditis and celiac disease.en10.4318/tjg.2010.0093info:eu-repo/semantics/closedAccessAutoimmune ThyroiditisCeliac DiseaseInsulin-Dependent Diabetes MellitusAutoimmune DiseaseGluten-Sensitive EnteropathyAdolescentsPrevalenceArticle213231235Q4WOS:0002836063000062-s2.0-7795768402720931425Q3109476