Nazli H.Mesut B.Özsoy Y.2024-06-122024-06-1220211300-4182https://search.trdizin.gov.tr/yayin/detay/513082https://hdl.handle.net/20.500.14551/17377Advances in technology have broken new ground in the area of new active pharmaceutical ingredients discovery. Although the number of newly discovered active ingredients increases, only a few of them manage to survive for further development. even if some of the discovered active ingredients have appropriate pharmacological activity, they are eliminated in the early stages of drug development due to their undesired physicochemical properties. Most of the time low solubility leads to bioavailability problems. increasing the solubility and hence bioavailability of an active pharmaceutical ingredient is an integral part of pharmaceutical technology and development. in the first part of this review, information about the methods that can be used to increase the solubility is given. in the second part, studies aiming to increase the solubility of aprepitant, a low-solubility active ingredient, are discussed. © 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.trinfo:eu-repo/semantics/closedAccessAprepitant; Bioavailability; Particle Size Reduction; Solid Dispersions; Solubility; Solubility Enhancement TechniquesAprepitant; Drug Activity; Drug Bioavailability; Drug Solubility; Physical Chemistry; ReviewReview Article4633253442-s2.0-85122758401Q3513082