Altinkok, CagatayAcik, GokhanKarabulut, Huseyin Riza FerhatCiftci, MustafaTasdelen, Mehmet AtillaDag, Aydan2024-06-122024-06-1220211042-71471099-1581https://doi.org/10.1002/pat.5478https://hdl.handle.net/20.500.14551/18379In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.en10.1002/pat.5478info:eu-repo/semantics/closedAccessAmphiphilicDrug ReleaseLithocholic AcidPhotopolymerizationCholic-AcidPhotoinitiated PolymerizationPoly(Ethylene Glycol)CopolymersAggregationTransportReleaseBindingPhArticle321248604868Q2WOS:0006871894000012-s2.0-85113231474Q2