Memiç Sancar K.Çelik O.Çil C.Başaran Ö.Demirci E.Ozan Tanık V.Yetim M.2024-06-122024-06-1220222630-5593https://doi.org/10.5505/anatoljfm.2022.26566https://search.trdizin.gov.tr/yayin/detay/1122535https://hdl.handle.net/20.500.14551/16907Objectives: Acetylsalicylic acid (aspirin) is commonly used with various indications, especially in the elderly population. This study aims to evaluate the prevalence of polypharmacy and aspirin use in patients aged ?80 years. Methods: The ASSOS trial is a cross-sectional, national registry study. This nonrandomized study was conducted by 30 cardiologists in 14 cities on the elderly (over the age of 80 years) who used aspirin (80–325 mg). Polypharmacy is described as an intake of five or more medicines daily. Results: A total of 309 patients were included in the study, and 146 (47.2%) of them were females. Aspirin treatment for primary prevention (PP) was reported to be given to 101 (32.7%) patients, and polypharmacy was detected in 198 (64.1%) patients. Major gastrointestinal bleeding was reported in 7 (3.5%) patients in the polypharmacy group and 0 (0.0%) patients in the without polypharmacy group (p=0.043). Minor bleeding was reported in 58 (29.3%) patients in the polypharmacy group and in 8 (7.2%) patients in the group without polypharmacy (p<0.001). Conclusion: Aspirin was reported to be used commonly among patients aged ?80 years for PP although the current guidelines do not recommend aspirin for PP in Turkey. Polypharmacy is still critical in the very elderly population and should be carefully considered in terms of complications. Copyright © 2023 Magnolia Press.en10.5505/anatoljfm.2022.26566info:eu-repo/semantics/openAccessAged; Aspirin; PolypharmacyArticle5279842-s2.0-85169574008Q41122535